Crossopteryx is a monotypic genus of flowering plants in the Rubiaceae family. The genus contains only one species, viz. Crossopteryx febrifuga, which is found . Crossopteryx febrifuga. Rubiaceae. (G. Don.) Benth. Crossopteryx febrifuga (Paul Latham). Crossopteryx febrifuga flower and fruit (Paul. Latham). Preparations of Crossopteryx febrifuga (Afzel.) Benth. (Rubiaceae) are widely used in Northern Nigeria in the therapeutic management of.

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These rats were approved for crossopyeryx by the AFC committee after reviewing the protocol. Pharmacological studies of Panacis japonici Rhizoma.

Preparations of the tree is used traditionally for symptomatic relief of dry cough and for treatment of septic wounds, respiratory infections, fever, dysentery and pain. Fresh stem bark of C.

West African Plants – A Photo Guide – Crossopteryx febrifuga (Afzel. ex ) Benth.

Afr J Pharm Pharmacol. Ethanol caused destruction of several glandular areas and febrkfuga infiltration of inflammatory cells into the sub mucosa areas. The ulcer lesions febriruga scored according to severity Larach and Malagelada, as follows: Twenty four hours fasted rats were randomized into 6 groups of 5 rats each. Misoprostol a synthetic analogue of prostaglandin E1 completely protected the mucosal layer against piroxicam-induced lceration.

Piroxicam produced focal haemorrhagic gastric lesions and inflammation of the stomach mucosa in the rats. Abstract Preparations of Crossopteryx febrifuga Afzel. Several areas of glandular destruction. This observation further highlights the safety of the extract as an analgesic without gastrointestinal side effects associated with the traditional NSAIDs.

Shows ulceration of mucosa layer of group treated with ethanol only Magnification X Stimulation of rat gastric mucosal leukotriene C4 crossoptetyx by ethanol and effect of gastric protective drugs. Evidence for protective and crossoperyx properties of rutin, a natural flavone, against ethanol induced crossoptrryx lesions. Discussion The results obtained from the study showed that the methanolic stem bark extract of Crossopteryx febrifuga possess anti-ulcerogenic activity in rats.

Several plants containing high amounts of saponins have been shown to possess antiulcer activity in several experimental bioassays Yamahara et al, ; Yesilada and Takaish, ; Morikawa et al, probably acting as an activator of mucus membrane protective factors Saito et al. Pharmacological screening and toxicology. Previous studies have shown that some tannins Salawu et al.


The ulcer lesions were scored according to severity Larach and Malagelada, as follows:. The primary cause of the pathogenic effects of NSAIDs in the stomach is crossoptwryx deficiency of endogenous prostaglandins required to maintain the mucosal barrier to luminal acid. Thus, illustrating the pharmacodynamic safety of the extract even in painful conditions associated with gastro-intestinal ulceration. The efficacy of the gastro-histoprotective effects of methanolic extract of Crossopteryx febrifuga against the piroxicam – induced gastric mucosa atrophy and ethanol-induced focal infiltration of inflammatory cells into mucosa areas, were comparable to that of misoprostol and cimetidine respectively.

Preparation of the plant extract Ceossopteryx stem bark was cleaned, air-dried for seven 7 days and crushed into coarse powder using a pestle and mortar. Thirty minutes later, all the rats in groups 2—6 were treated with piroxicam.

In the ethanol-induced ulcer assay, the control group treated orally with ethanol clearly febrrifuga the expected characteristic zone of necrotizing mucosal lesions.

Crossopteryx febrifuga

Table 3 Results of Histopathology examinations. Focal infiltration of inflammatory cells into mucosa areas. Drugs that febrivuga effective against peptic ulcer act either by reducing the aggressive factors on the gastro-duodenal mucosa or by increasing mucosal resistance against them Larach and Malagelada,Salawu et al.

The method described by Salawu et al. In conclusion this study illustrated the safety of Crossopteryx febrifuga in gastrointestinal tract when used as an antiinflammatory analgesic agent that could be developed for management of painful inflammatory disorders.

This class of secondary compounds is able to protect the gastric mucosa against a variety of antiulcerogenic agents, particularly through scavenging properties on oxygen radicals by inhibition of nitric oxide Synthase activity Di Carlo et al.

The stomachs were removed, opened along the greater curvature, rinsed with slow running water.

Table 1 Effect vrossopteryx Crossopteryx febrifuga on ethanol-induced gastric ulceration in rats. Introduction Nonsteroidal anti-inflammatory drugs NSAIDswhich act as non-selective cyclooxygenase COX inhibitors, are commonly used to treat pain and inflammation despite the risk of major upper gastrointestinal complications Venkova et al. Effect of the Crossopteryx febrifuga extract on piroxicam-induced gastric ulceration.


Histopathological studies further confirmed the extract’s mucosal protective effect in that it inhibited both piroxicam – and ethanol induced mucosal atrophy, infilteration by eosinophils and lymphoplasma cells in febrifjga wall glandular destruction, focal infiltration of inflammatory cells into mucosa areas. The crossopterjx of deaths in each group within 24 h was recorded and the final LD 50 values were calculated as the geometric mean of the highest nonlethal dose with no deaths and the lowest lethal dose where febeifuga occurred.

Preparations of Crossopteryx febrifuga Afzel. The extract profoundly antagonized the Piroxicam- induced ulceration in rats. Adv Prostaglandin Thromboxane Leukot Res. The phytochemical analyses carried out on methanolic stem bark extract of Crossopteryx febrifuga by Salawu et al. Table 2 Effect of the Crossopteryx febrifuga extract on piroxicam-induced gastric ulceration. Materials and Methods Collection plant material Fresh stem bark of C.

One of such therapeutically useful croesopteryx plant is Crossopteryx febrifuga Benth, Family Rubiaceaea twisted tree with conspicuous tubular flowers, which is widely distributed throughout the Savannah region of Central, East and West Africa.

Ethanol retards gastric epithelial restoration in monolayer cultures. These results showed that the extract had no deleterious effects and was cytoprotective on the gastrointestinal tract git. Studies by Santo et al.

The studies were carried out following the principles of good laboratory practice and animal handling National Institutes of Health Guide for the Care and use for Laboratory animals; Publication No. In the present study, the methanolic stem bark febrfiuga of Crossopteryx febrifuga was evaluated against ethanol- and piroxicam-induced ulceration in rats.